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HPTuners is the only thing set up for tuning the stock PCM (which is plenty for practically everyone). Anything super hardcore you can wire in a standalone engine management system and tune with that, but that's extreme.
Can't help you on the injectors. Not sure who all have upgraded them on the 3400. At least with the 2.4L we have j-body.org as a massive reference for mods and upgrades. Not sure on the 3400 unless maybe 60degreeV6 has further info for ya.
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