I run that head unit in my '00 ho, fits fine, of course I had to cut this plastic thing that sticks out in the back of the car's mount so the RCAs could allow the headunit it to slide all the way back, but it was really no big deal. You most likely will need an antenna adapter which is real cheap at Wal-Mart.
As far as the back 6x9s, I would leave the stock amp (if you aren't planning on upgrading to an after market amp for them). Replace the 6x9s to the ones you like most. I have JL-TR 6x9s in the stock mounts and there is plenty of clearance between the stock grill and the top of the speaker.
If you need anymore help, just ask
